This study aims to analyze the process of the formation of knowledge in Sūrat al-Anʿām (verses 74–104) through the lens of Charles Sanders Peirce’s triadic system of semiotics. The central research question examines how the Qurʾān, through a network of signs, guides human beings from erroneous perception and the signifying system of polytheism toward a monotheistic understanding. Within this framework, the selected verses are examined as a dynamic semantic system in which natural elements, cosmic events, and the epistemic experiences of Abraham (peace be upon him) function as signs that ultimately refer to the final interpretant—the truth of divine unity. The study adopts a descriptive–analytical method, and the data are analyzed according to Peirce’s triadic model consisting of the representamen, object, and interpretant. The findings indicate that the verses under investigation depict a gradual process in the formation of knowledge. In the first stage, deviant signs—such as idols or induced fears—are presented as representamens lacking a genuine relation to their objects, thereby producing a disruption within the system of signification. In the second stage, Abraham’s cosmic experience in observing the star, the moon, and the sun demonstrates that although natural phenomena may function as signs, their transient nature prevents them from serving as ultimate referents. Consequently, these experiences lead to a revision of the interpretant and a transition beyond unstable signifiers. In the third stage, the Qurʾān introduces a coherent system of valid signs by referring to natural phenomena, cosmic order, and biological processes, all of which guide human beings toward a gradual recognition of the Creator. Ultimately, the concept of baṣīrah (insight) is presented as the human capacity to correctly interpret signs and attain certainty. The study concludes that Sūrat al-Anʿām presents a semiotic structure for epistemic guidance in which the movement from perceptual error to monotheistic certainty unfolds through the process of interpreting signs. In this way, the Qurʾān organizes a network of natural, cosmic, and historical signs that forms an epistemological framework through which human beings, by revising their interpretation of the world, arrive at the recognition of divine unity.